Interstate 75: Take Exit 131 (Daniels Parkway) west to Summerlin Road. Turn left on Summerlin Road and follow it to the Sanibel Causeway (a $6 toll). Drive across and onto Sanibel Island. At the four-way stop sign at Periwinkle Way, either a right or left turn will lead you to beaches, shops, accommodations, etc. To reach Captiva, turn right on Tarpon Bay Road and left on Sanibel-Captiva Road. Drive about eight miles. Cross Blind Pass bridge and you’re on Captiva. That takes another 15 to 30 minutes.
Interstate 95: If you’re driving into Florida from the North via Jacksonville, take I-95 south to I-4; take I-4 west to I-75, then follow the directions above. If you’re on Florida’s east coast and choose to bypass the Orlando and Tampa areas (both off I-4), take I-95 south to Fort Lauderdale and follow the signs directing you to I-75 west (toward Naples).
Car Rentals: You’ll need a valid driver’s license, proof of auto insurance and a major credit card. (Some rental agencies have minimum age requirements, too.) Nearly all major car rentals are available at Southwest Florida International Airport; it’s best to make reservations before you arrive.